Age Reversal with GHK-Cu Copper Peptide

Content Courtesy: http://reverseagingwithghk.com/

by Loren Pickart, Discoverer of GHK and many of its biological effects
BA Chemistry and Mathematics, University of Minnesota
PhD Biochemistry, University of California, San Francisco

The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive.

The Broad Gene Institute found GHK induced a significant change in the gene expression, UP or DOWN, in 31.8% of the human genes.

At levels of change greater than 50% UP or DOWN, it affected 4,192 human genes, dramatically affecting the following categories of concern:

Skin & Hair

GHK was first studied for wound healing (1983+) and later for its effects on skin and hair. In many controlled, peer-reviewed published articles, GHK was found to:

• TIGHTENED LOOSE SKIN and thicken older skin

• Repaired protective skin barrier proteins

• Improved skin firmness, elasticity, and clarity

• Reduced fine lines, DEPTH OF WRINKLES, and overall appearance

• Smoothed rough skin

• Reduced photodamage, mottled hyperpigmentation, skin spots and lesions

• Improved overall appearance

• Protected skin cells from UV RADIATION

• INCREASED HAIR GROWTH and thickness, enlarge hair follicle size

• Accelerated WOUND HEALING, but better when used in liposomes due to its sensitivity to carboxypeptidase breakdown effects

Anti-Cancer Actions

• Topped 1,309 bioactive compounds as the Broad Institute computer recommended molecule for the treatment of human METASTATIC COLON CANCER

• GHK, at 1 nanomolar, reset the PROGRAMMED CELL DEATH system in human cancer cells (human neuroblastoma, leukemia, and breast cancer) but did not affect healthy cells

• GHK-copper plus ascorbic acid suppressed a sarcoma in mice

• GHK inhibited NFKB p65 which is believed to promote cancer growth

• REPAIRED DAMAGED DNA at cellular level at 1 nanomolar (47 genes up, 5 genes down)

• GHK-copper induced cell differentiation

• Reset 84 genes to growth inhibition or cancer inhibition

Lung Protections

• Topped 1,309 bioactive compounds as Broad Institute computer recommended molecule for treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Restored healthy function in COPD affected cells at 10 nanomolar

• PROTECTED LUNG CELLS from damage by both bleomycin and lipopolysaccharide-induced injury

• In fetal lung cells, GHK-Cu (at concentrations of 0.1, 1.0, and 10 nanomolar) produced dose-response changes in 329 HUMAN FETAL LUNG GENES of the extracellular matrix

Antioxidant / Anti-Inflammation

• INCREASED SOD1 ACTIVITY. Suppressed toxic products of lipid oxidation alpha,beta-4-hydroxy-trans-2-noneal and acrolein, peroxyl radicals, hydroxyl radicals, p38 MAPK, IL-6, IL-17, TNF alpha, and strongly suppressed NFKB, a molecule which is believed to be a primary cause of many diseases of aging

• Completely BLOCKED CU2+ OXIDATION of low density lipoproteins while SOD1 gave only 20% blocking

• BLOCKED RELEASE OF OXIDIZING IRON from ferritin

Brain & Nerves

• Altered expression of human genes important in NEURON FUNCTION by 50%, plus or minus, with 408 UP and 230 DOWN

• Induced strong ANTI-ANXIETY AND ANTI-AGGRESSION effects in rats within 12 minutes at a weight equivalent of 35 micrograms in 70 Kg humans

• Induced ANTI-PAIN ACTIVITY in rats within 12 minutes

• Alleviated neuronal apoptosis due to INTRACEREBRAL HEMORRHAGE

• Now used clinically in humans for the treatment of damaged spinal segments in the neck. Treatment was for 20 days with a daily injection of 0.25 mg GHK-Cu into the skin around the damaged area. The cost of GHK-Cu is about $0.01 a milligram

Stem Cells & Other Actions

• Caused adult MCS STEM CELLS to produce more growth factors, increased stem cell differentiation

• Enhanced activity of alginate hydrogels for human cord blood MCS STEM CELL OSTEOGENESIS

Additional Actions of GHK

• Increased the healing of many tissues (SKIN, STOMACH, INTESTINE LINING, BONE TISSUE)

• Strongly chemo-attracted CAPILLARY CELLS, mast cells, and macrophages

• Strongly activated genes of the UBIQUITIN PROTEASOME SYSTEM used for cell cleansing.
(41 genes up, 1 gene down)

• BLOCKED CORTISONE's anti-regeneration effects.

• Suppressed the INSULIN and insulin-like system that reduces lifespan in roundworms

• Reduced FIBRINOGEN synthesis. Fibrinogen levels are the top predictor of cardiovascular heart disease

• Increased myostatin gene expression 9.4 fold. Myostatin inhibits heart failure.